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Cyclosporine Soft Gel Capsules

Cyclosporine Soft Gel Capsules
Cyclosporine Soft Gel Capsules
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Product Code : 505
Price And Quantity
  • Minimum Order Quantity
  • 300 Box
  • Price
  • 74 INR/Box
Product Specifications
  • Drug Type
  • General Medicines
  • Ingredients
  • glycerin, glyceryl caprylate
  • Physical Form
  • Capsules
  • Suitable For
  • Adults
  • Storage Instructions
  • Cool and Dry Place
Product Description
Cyclosporine lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.Cyclosporine is used to prevent organ rejection after a kidney, heart, or liver transplant. Cyclosporine is also used to treat severe psoriasis or severe rheumatoid arthritis.

Pharmacology:

Pharmacodynamic Properties Of Cyclosporine
Used in immunosuppression for prophylactic treatment of organ transplants, cyclosporine exerts specific and reversible inhibition of immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited. The T1-helper cell is the main target, although the T1-suppressor cell may also be suppressed. Sandimmune (cyclosporine) also inhibits lymphokine production and release including interleukin-2.
Pharmacokinetic Properties Of Cyclosporine
  • Absorption:
    The absorption of cyclosporine from the gastrointestinal tract is incomplete and variable. The extent of absorption is dependent on the individual patient, the patient population, and the formulation.
  • Protein Binding:
    In the plasma, approximately 90% is bound to proteins, primarily lipoproteins. In blood, the distribution is concentration dependent. Approximately 33% to 47% is in plasma, 4% to 9% in lymphocytes, 5% to 12% in granulocytes, and 41% to 58% in erythrocytes.
  • Metabolism:
    Hepatic, extensively metabolized by the cytochrome P450 3A enzyme system in the liver. It is also metabolized in the gastrointestinal tract and kidney to a lesser degree. The metabolites are significantly less potent than the parent compound. The major metabolites (M1, M9, and M4N) result from oxidation at the 1-beta, 9-gamma, and 4-N-demethylated positions, respectively.
  • Route Of Elimination:
    Elimination is primarily biliary with only 6% of the dose (parent drug and metabolites) excreted in the urine. Only 0.1% of the dose is excreted in the urine as unchanged drug.
Pregnancy & Lactation
Pregnancy Pregnant women receiving immunosuppressive therapies after transplantation, including cyclosporin and cyclosporin-containing regimens, are at risk of premature delivery.
Breast-Feeding Cyclosporin passes into breast milk. The ethanol content of the Neoral formulations should also be taken into account in women who are breast-feeding
Contraindications
Hypersensitivity to the active substance or to any of the excipients.
Side Effects
Very rare but the common side effects are:
●Shaking
●Headache
●Dizziness
●Unusual growth of body hair,
●Nausea/vomiting
●Diarrhea
●Stomach upset

Trade Information
  • Payment Terms
  • Cash in Advance (CID), Cash Advance (CA)
  • Supply Ability
  • 300 Box Per Month
  • Delivery Time
  • 1 Months
  • Sample Available
  • Yes
  • Sample Policy
  • Sample costs shipping and taxes has to be paid by the buyer
  • Main Export Market(s)
  • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
  • Main Domestic Market
  • All India

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