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Home » Products » GRISEOFULVIN 500 MICRONIZED SCORED TABLETS » Nutraceutical Tablet » Fexofenadine & Montelukast Tablet

Fexofenadine & Montelukast Tablet

Fexofenadine & Montelukast Tablet
Fexofenadine & Montelukast Tablet
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Product Code : 227
Product Description
Montelukast is a Leukotriene receptor antagonists. (is used for maintenance treatment of asthma and to relive symptoms of seasonal allergies) It is a selective and orally active leukotrien antagonist that inhibits the cysteinyl leukotrien CysLT1 receptor.
Fexofenadine Hydrochloride is a second - generation antihistamine pharmaceutical drug (is prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hay fever).

Indications and Usage:
Asthma, Chronic Allergic, Seasonal Allergies, Used For Hay Fever or Allergies.

Rationale of Combination:
This drug continues to work for 12 hr - 24 hr. A large study found that Cetirizine was associated with an increased risk of heat arrhythmias comparison to Fexofenadine.
It has been demonstrated by recent studies that the treatment of allergic rhinitis with concomitant administration of an antileukotrien (montelukast) and an antihistamine (Fexofenadine), shows significantly better symptoms relief compared with the modest improvement of rhinitis symptomatology with each of the treatments alone.

(FEXOFENADINE HCL) (MONTELUKAST)

HAY FEVER OR ALLERGIES ASTHMA
What is it? A bodily reaction to usually harm -less substances in the environment - most often pollen, mold, and animal dander. A condition in which the tubes in the lungs
become swollen and narrow, making it difficult
to breathe and get enough oxygen in and out
of your lungs. Can be triggered by pollen, mold, dander, smoke and air pollution, exercise, other illness, stress, and some drugs.
Why do some people get it? Generic predisposition Generic predisposition

Can strike people of all ages, but often shows up in childhood and teen years. Infection can trigger asthma


Usually shows up in childhood; less commonly strikes over age 25.
Main Symptoms Sneezing Mild attacks:

Teary eyes Feeling out of breath

Itchy nose and throat Tightness in chest

Congestion, runny nose Wheezing

Clear nasal discharge Coughing

Cough (Sometimes)


Severe attacks:

Difficulty breathing (sometimes) Very difficult to breath

Headache (sometimes) Difficulty talking


Skin feels if it's pulled tightly around ribs
and neck

Itchy red patches on skin (hives) Rapid heartbeat






Main Treatment
Options
Nasal Sprays Inhalers and nebulizers containing short
acting bronchodilators.

Antihistamine Inhalers containing steroids

Decongestants Leukotriene - block pills

Allergy shots Steroid pills or shots


Immune - system modifiers

Drug Interaction:
BEFORE TAKING THIS MEDICINE TELL THE DOCTOR ABOUT ANY MEDICAL PROBLEMS AN ALLERGIES RELATED ASTHMA.
Some medicines may affect how patient's works, or other medicine work. If anyone is taking or has recently taken other medicines, including those obtained without a prescription.
Theophylline, predisolone, oral contraceptives, terfenadine, digoxin, warafin, thyroid hormones & sedative hypnotics, Antifungal medicine (ketokonazole), aspirin, fruit juice.theophylline, erythromycin, antacids, cimetidine

Indication:
●Montelukast causes inhibition of airway cysteinyl leukotriene receptors as demonstrated by the ability to inhibit bronchoconstriction due to inhaled LTD 4 in asthmatics.
●For Chronic Allergic conditions like seasonal allergic rhinitis, perennial allergic rhinitis, Rhinitis associated with Ashtma.
●Monteluakst may offer an alternative to Theophylline as add - on therapy is asthma poorly controlled by shortacting beta - agonist and inhaled corticosteroids.
●Montelukast causes inhibition of airway cysteinyl leukotriene receptors as demonstrated by the ability to inhibit bronchoconstriction due to inhaled LTD 4 in asthmatics.
●For Chronic Allergic conditions like seasonal allergic rhinitis, perennial allergic rhinitis, Rhinitis associated with Ashtma.
Monteluakst may offer an alternative to Theophylline as add - on therapy is asthma poorly controlled by shortacting beta - agonist and inhaled corticosteroids.

Fexofenadine is antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms sneezing, itching, watery eyes, and runny nose.
It is used to treat the symptoms a seasonal allergies (hay fever) in adults and children also used in skin itching and hives caused by a conditions called chronic idiopathic urticaria in adults and children.

Adverse Effects:
●Nausea, diarrhea, upset stomach
●Menstrual cramps
●Drowsiness, Tired feeling.
●The most commonly reported adverse reactions were headache, asthma and upper respiratory tract infections; however none were significantly different in frequency between the groups.

Contraindications:
Hypersensitivity, pregnant patients, patients with blood and lymphatic system disorder and psychiatric disorder.

Conclusion:
This is a new combination for severe allergy which could be a sign of asthma; most people who have asthma also have underlying allergies can take this medicine. In people who have allergies and allergy - induced asthma the body's immune system overreacts when exposed to otherwise harmless substances, such as pollen, dust mites, mold spores, and animal dander.
In people with allergies are at much higher risk of developing asthma and sinus infections (sinusitis) and the inflammation that a compares the allergic response can damage the respiratory system and make more susceptible to lung infection like pneumonia.

Asthma often co-exists in patients with persistent allergic rhinitis. The combination of Fexofenadine + Montelukast equally reduces the serum SICAM - 1 concentration and gives the same clinical effect in pateings The study shows to investigate the effects of treatment with a combination of antihistamine (Fexofenadine) and an antileukortiene (Montelukast) in patients with persistent allergic rhinitis and newly diagnosed asthma.

The use of Moneluakst in the treatment of seasonal allertic rhinitis is more effective than placebo, an effective as Loratidine and in combination with antihistamine is perhaps more effective for allevialing congestion symptoms than antihistamine alone.
From the above discussion, it can be concluded that this medicine could improve the quality of life of patients with allergic rhinitis as well as asthma in addition to being efficacious as immunotherapy in seasonal allergic rhinitis. Moreover it has a considerable safety profile, with persistent results.This combination offers as effective, well tolerated and convent treatment option for children with asthma and allergies.

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