Itraconazole Dusting Powder

Itraconazole 1% Dusting Powder is a broad spectrum antifungal medicine used to treat skin infections like athlete's foot, jock itch, ringworm, etc. It is also used for relieving symptoms of these infections such as burning, itching, and cracking of the skin. It works by stopping the growth of fungi.
Indications:
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Pharmacology:

Pharmacological & Pharmacodynamic Properties:
Itraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole.

Pharmacokinetic Properties:
Absorption:
Itraconazole is rapidly and almost completely absorbed with maximum plasma concentrations (Cmax) achieved 1-2 hours after dosing.
Protein Binding:
99.8%
Metabolism:Itraconazole is extensively metabolized by the liver into a large number of metabolites, including hydroxyitraconazole, the major metabolite. The main metabolic pathways are oxidative scission of the dioxolane ring, aliphatic oxidation at the 1-methylpropyl substituent, N-dealkylation of this 1-methylpropyl substituent, oxidative degradation of the piperazine ring and triazolone scission.

Contraindications:
It is contraindicated for patients who have shown hypersensitivity to Itraconazole.

Side Effects:
Though very rare but some of the reported side-effects of this include:

• Abdominal pain
• Nausea and vomiting
• Vaginal bleeding
• Skin rash
• Redness of skin
• Vaginal infection