Cefuroxime Axetil Tablet

Cefuroxime Axetil Tablet

70 INR/Box

Product Details:

  • Purity 99%
  • Formulations Type General Drugs
  • Formulations Form Tablets
  • Gender/Age Group Adult
  • Storage Instructions Store in Cool
  • Supply Ability : 300 Box Per Month
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Price And Quantity

  • 300 Box
  • 70 INR/Box

Product Specifications

  • Tablets
  • Store in Cool
  • General Drugs
  • Adult
  • 99%

Trade Information

  • Cash in Advance (CID), Cash Advance (CA)
  • 300 Box Per Month
  • 1 Months
  • Yes
  • Sample costs shipping and taxes has to be paid by the buyer
  • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
  • All India

Product Description

Cefuroxime Axetil is a semisynthetic, broad-spectrum cephalosporin antibiotic for oral administration.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefuroxime axetil and other antibacterial drugs, cefuroxime axetil should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Indications and Usage:
Pharyngitis/Tonsillitis, Acute Bacterial Otitis Media, Urinary Tract Infections, Gonorrhea, Lyme Disease (erythema migrans).

Mechanism of Action:
Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor.

Pharmacokinetics:
Bioavailability
37% on empty stomach, up to 52% if taken after food
Half-life
80 minutes
Excretion
Urine 66-100% Unchanged


Pharmacology:
Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi. Cefuroxime axetil is the prodrug.
Absorption:It is absorbed from the gastrointestinal tract. Absorption is greater when taken after food (absolute bioavailability increases from 37% to 52%).
Protein binding:50% to serum protein.
Metabolism:The axetil moiety is metabolized to acetaldehyde and acetic acid.
Half life:Its half life is Approximately 80 minutes following intramuscular or intravenous injection.

Side Effects:
Upset stomach, vomiting, diarrhea,stomach pain.

Storage:
Below 40 ° C. Protect from Sunlight.

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