Osteoarthritis is one of the most prevalent and disabling chronic diseases affecting the elderly. Itsmost prominent feature is the progression destruction of articular cartilage which results in impaired joint motion. severe pain and ultimately disability. The term 'Nutraceutical' was coined from nutrition and 'Pharmaceutical' in 1989 and was originally defined as Food that provides medical or health benefits including the prevention and/ or treatment of a disease. Nutraceuticals and dietary supplements have long been used in traditional medicine and there is a considerable evidence that nutraceuticals may play an important role in inflammation and joint destruction in Osteoarthritis.
People take supplements for all kind of reasons, usually relating to their health. Certain nutrients are essential for keeping the body functioning , but expert agree the most people can get enough of these from eating balanced diet and in, and in the case of vitamin D, from getting enough sunlight. On the other hand, there is good evidence that certain supplements may be beneficial to health of certain group of people, such the elderly, pregnant women.
Collagen is a primary connective tissue; it represents close to 30 % of animal protein matter. collagen is a key protein in the body that ensures the cohesion, elasticity and regeneration of skin, cartilage and bone. esearchers have produced several keys for understanding how collagen peptides work. They have also shown that the extra-cellular matrix in which cells grow is decisive in their differentiation. Studies have demonstrated that when collagen peptides metabolites are present in this matrix, osteoblasts, the cells responsible for bone formation, are preferentially stimulated, instead of osteoclasts, the cells involved in bone resorption, this triggers bone formation.
Collagen Peptides may be effective on bone metabolism by inducing differentiation andmaturation of osteoblast and stimulating their activity. Bone turnover is thus modulated, preventing bone resorption during the natural phenomenon of bone loss (osteopenia) and increasing bone solidity. Studies have demonstrated the benefits of collagen peptides on joint and bone health. In those studies, Collagen Peptides may have been shown to support bone health through increased bone and mineral density, increased bone size, less brittle bones, and the stimulation of osteoblast activity in spite of osteoclasts activity (stimulating bone growth).
Glucosamine Sulphate Potassium Chloride:
Glucosamine sulfate can improve pain and movement in knees affected by osteoarthritis. Itseems to work about as well as some nonprescription pain medications. But glucosamine takes about twice as long to work, four weeks instead of two. There is some evidence that glucosamine sulfate may actually keep the joint problems from getting worse. Other pain relievers can reduce the pain but do not prevent the disease from slowly destroying more of the joint. Glucosamine sulfate might not be as effective for reducing pain in more severe, long-standing osteoarthritis.
Boswellia Serrata is a gum resin extracted from a tree, which is sometimes burnt (the entire species of Boswellia is commonly known as Frankinsence. Boswellia Serrata, via its active boswellic acids, appears to be a novel inhibitory of a pro-inflammatory enzyme called 5-Lipoxygenase and may possess other anti-inflammatory effects such as nF-kB inhibition.These anti-inflammatory effects have been investigated for their benefits in osteoarthritis (OA), and it appears that oral Boswellia supplements can suppress pain and immobility associated with OA quite significantly with the effects taking as little as a week to occur. The studies are well conducted, but funded by the producers of the tested supplements.
As osteoarthritis weakens the cartilage of a joint, the bone underlying the cartilage undergoeschanges. Vitamin D assists the body in the absorption of calcium and has been used for the treatment and prevention of osteoporosis (a condition characterized by bone thinning). It has been suggested that suboptimal vitamin D intake and blood levels might impair the body's normal protection from these bone changes.
Vitamin CÂ is a powerful antioxidant in the body. By neutralizing free radicals, vitamin C helps reduce inflammation and damage that occurs in osteoarthritis. Vitamin C is also necessary for the production of healthy connective tissue and cartilage, and may even be able to help undo some of the damage that has already been done. The osteoarthritis of patients who get plenty of vitamin C in their diets seems to progress more slowly compared to people who have diets low in vitamin C.
Ã¢ÂÂ Effective in osteoarthritis
Ã¢ÂÂ Helps to improve the integrity and flexibility of bones
Ã¢ÂÂ Reduce bone resorption
Ã¢ÂÂ Improves immune function
Ã¢ÂÂ Maintains connective tissue
Mechanism of action:
This combination plays an important role in making glycosaminoglycans and glycoproteins, which are essential building blocks of many parts of your joints, including ligaments, tendons, cartilage and synovial fluid. It's been suggested that the way these parts of your joint are built and maintained contributes to the development and the progression of osteoarthritis. Giving glucosamine can delay the breakdown of cartilage as well as rebuild it.